P2NP CAS 705-60-2
1-Phenyl-2-nitropropene cas 705-60-2, or simply pheny-2-nitropropene, or P2NP, as it is commonly referred to, is a chemical compound from the aromatic group of compounds, with the formula CgHgNOz.lt isa light-yellow crystalline solid with a distinct smell.Phenyl-2-nitropropene is used in the pharmaceuticalindustry to manufacture the drug Adderall, an amphetamine mixture used to treat ADHD and narcolepsy.P2NP and other similar nitrostyrenes are also employed in the clandestine manufacture of drugs of theamphetamine class, and are listed as drug precursors in many countries.
Product Information:
| Product Name: | 1-Phenyl-2-nitropropene |
| Synonyms: | 1-(PHENYL) 2-NITROPROPENE;2-NITROPROP-1-ENYLBENZENE;2-NITRO-1-PHENYLPROPENE;BETA-METHYLNITROSTYRENE;BETA-METHYL-BETA-NITROSTYRENE;TIMTEC-BB SBB003925;TRANS-BETA-METHYL-BETA-NITROSTYRENE;trans-β-methyl-β-nitrostyrene |
| CAS NO: | 705-60-2 |
| EINECS: | 627-363-3 |
| Molecular Formula: | C9H9NO2 |
| Molecular Weight: | 163.17 |
| Melting Point: | 63-65 °C (lit.) |
| Boiling Point: | 263.0±9.0 °C(Predicted) |
| Density: | 1.141±0.06 g/cm3(Predicted) |
| Appearance: | Yellow Crystalline Powder |
| Storage: | 2-8°C |
| Solubility: | Acetone, Chloroform, Dichloromethane, Methanol |
| Applications: | (2-Nitropropenyl)benzene is a derivative of styrene (S687790), which exhibits herbicidal and antibacterial properties. |
synthesis of amphetamine sulphate using p2np
The most common route of synthesis is by the Leuckart method.This uses (P2P, BMK, phenylacetone) and reagents such as formic acid, ammonium formate or formamide to yield a racemic mixture of the R- and S-enantiomers. A much less common, but stereoselective, method is by reduction of the appropriate diastereoisomers of norephedrine or norpseudoephedrine. These precursors (1-phenyl-2-propanone, norephedrine and norpseudoephedrine) are listed in Table I of the United Nations 1988 Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances. The corresponding EU legislation is set out in Council Regulation (EEC) No 3677/90 (as later amended), which governs trade between the EU and third countries.
simple p2np synthesis
In the lab, phenyl-2-nitropropene is produced by the reaction of benzaldehyde and nitroethane in the presence of a basic catalyst like n-butylamine. The reaction is a nitroaldol reaction, and is a variant of a Knoevenagel condensation reaction, which is one of a broader class of reactions called Henry condensations, or simply Henry reactions. These are named after the German chemist Emil Knoevenagel, and the Belgian chemist Louis Henry, respectively.
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