CAS 28578-16-7: An Overview of PMK Ethyl Glycidate


PMK Ethyl Glycidate, also known as 3-[3′,4′-(methyleendioxy)-2-methyl glycidate], with the chemical formula C12H12O5 and CAS number 28578-16-7, is an organic compound that belongs to the class of glycidate esters. It is a key intermediate in the synthesis of various substances, including pharmaceuticals and fragrances. This article provides an overview of the uses, synthesis, and properties of PMK Ethyl Glycidate.

I. Synthesis of PMK Ethyl Glycidate:

A. Chemical Reactions:

PMK Ethyl Glycidate can be synthesized through several chemical reactions. One common method involves the condensation of piperonal (CAS 120-57-0) with ethyl chloroacetate (CAS 105-39-5) using a suitable base and solvent. The reaction leads to the formation of PMK Ethyl Glycidate, which can be further purified and isolated.

B. Alternative Synthesis Routes:

In recent years, alternative synthesis routes for PMK Ethyl Glycidate have been explored to address regulatory restrictions and improve the efficiency of production. These routes involve the use of different starting materials and catalysts, enabling the synthesis of PMK Ethyl Glycidate in a more sustainable and economical manner.

II. Properties of PMK Ethyl Glycidate:

A. Physical Properties:

PMK Ethyl Glycidate is a colorless to pale yellow liquid with a fruity aroma. It has a molecular weight of approximately 236.22 g/mol and a boiling point of around 160-165°C. The compound is slightly soluble in water but exhibits good solubility in organic solvents such as ethanol and ether.

B. Chemical Properties:

PMK Ethyl Glycidate possesses a glycidate ester functionality, which makes it reactive in various chemical reactions. It can undergo hydrolysis to form the corresponding carboxylic acid. Additionally, the compound can be used as a building block in the synthesis of complex organic molecules.

III. Applications of PMK Ethyl Glycidate:

A. Pharmaceutical Industry:

PMK Ethyl Glycidate is a crucial intermediate in the synthesis of pharmaceutical compounds. It serves as a precursor for the production of substances with therapeutic properties, including certain anticoagulants, cardiovascular drugs, and analgesics. Its unique structure allows for the introduction of specific functional groups required for drug development.

B. Fragrance and Flavor Industry:

The compound finds applications in the fragrance and flavor industry. It contributes to the fruity and floral aroma of various perfumes, cosmetics, and food products. PMK Ethyl Glycidate enhances the olfactory experience and helps create distinctive scents and flavors.

C. Research and Development:

PMK Ethyl Glycidate plays a vital role in research and development activities. It is utilized as a starting material for the synthesis of new compounds, enabling scientists to explore novel chemical methodologies and investigate potential applications in different fields, such as medicine, materials science, and organic chemistry.


CAS 28578-16-7, PMK Ethyl Glycidate, is a versatile compound with significant applications in the pharmaceutical, fragrance, and flavor industries. Its synthesis can be achieved through various chemical reactions, and alternative routes are being explored to improve efficiency. The compound’s unique properties, such as its fruity aroma and reactivity, make it valuable as an intermediate in the production of pharmaceutical substances and as an ingredient in fragrances and flavors. Ongoing research and development continue to explore new applications and synthesis methods for PMK Ethyl Glycidate, further expanding its potential uses in various fields.

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