2-bromo-4-methylpropiophenone CAS 1451-82-7

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2-Bromo-3-methylpropiophenon CAS 1451-83-8

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2-Bromo-3-methylpropiophenone, identified by CAS number 1451-83-8, holds a pivotal role as a chemical cornerstone in various industries. It serves as a crucial raw material in the synthesis of agrochemicals and other refined chemicals. With an extraordinary 99% high purity, our product guarantees optimal outcomes in every application.

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2-bromo-4-methylpropiophenone uses

1451-82-7 usually used as the intermediate and raw material in the fine chemistry industry. Specifically, this chemical can act as the intermediate in the synthesis of 4-methyl methcathinone HCl, which is used as the sample for development and validation of a presumptive colour spot test method for the detection of piperazine analogues in seized illicit materials.Moreover, this compound may function as an effective ingredient to prepare the therapeutically useful 1-phenyl-2-piperidinoalkanol derivatives.In addition, this substance has been demonstrated to be involved in the preparation of a pharmaceutical composition comprising a pyrrole derivative, which shows a desirable activity for the treatment pollakiuria or urinary incontinence.

2-bromo-4-methylpropiophenone synthesis

14.8 g (0.1 mol) of 4′-methylpropiophenone are introduced into 100 ml of chloroform, in the presence of a small amount of finely ground aluminium chloride, and a solution of 15.9 g (0.1 mol; 5 ml) of bromine, in 20 ml of chloroform is added dropwise whilst cooling with an ice bath. The mixture is left to react overnight at ambient temperature. It is then filtered, the solvent is evaporated off from the filtrate and the crystalline residue is washed with diethyl ether. 21.5 g of crystals are collected.

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